Saccharin Sodium/Sodium saccharin, also known as sodium ortho phenylsulfonamide, was developed in 1879 and is the earliest artificially synthesized non nutritive sweetener used. It is soluble in water and has a sweetness of 200-500 times that of sucrose in a dilute solution. When the concentration is high, it has a bitter taste. When heated under acidic conditions, the sweetness disappears and can form a bitter ortho aminosulfonic acid. It is used as a sugar substitute for patients with obesity, hyperlipidemia, diabetes and dental caries because of its low calorie, non absorption, and automatic excretion with urine and urine. In addition, it can also be used as a brightener for electroplating nickel chromium, a blood circulation measuring agent, a penetrant, etc., with a wide range of uses.